{"id":945,"date":"2023-11-03T03:39:43","date_gmt":"2023-11-03T03:39:43","guid":{"rendered":"https:\/\/economicherald.net\/?p=945"},"modified":"2023-11-03T03:39:43","modified_gmt":"2023-11-03T03:39:43","slug":"data-shows-argenicas-drug-inhibits-another-main-cause-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/economicherald.net\/?p=945","title":{"rendered":"Data shows Argenica\u2019s drug inhibits another main cause of Alzheimer\u2019s disease"},"content":{"rendered":"<p>Argenica Therapeutics preclinical data shows ARG-007 inhibits abnormal tau proteins \u2013 a main cause of Alzheimer\u2019s disease<br \/>\nGlobal Alzheimer\u2019s disease market set to grow at 16.2% CAGR from now to 2030<br \/>\nThe company is progressing in vivo animal studies to confirm efficacy<\/p>\n<p>\u00a0<\/p>\n<p><strong>Argenica Therapeutics says preclinical data shows its ARG-007 drug inhibits yet another of the main abnormal proteins which causes Alzheimer\u2019s disease.<\/strong><strong>\u00a0<\/strong><\/p>\n<p>In August, the company reported the drug caused an 84% reduction in cellular uptake of Alpha-Synuclein (\u03b1-syn), <a href=\"https:\/\/stockhead.com.au\/health\/arg-007-to-prevent-aggregation-of-key-neurodegenerative-protein-linked-to-parkinsons-and-alzheimers\/\"><strong>a key hallmark linked to neurodegenerative diseases<\/strong><\/a> like Parkinson\u2019s and Alzheimer\u2019s.<\/p>\n<p>The market opportunity is huge. The global Alzheimer\u2019s disease therapeutics market size was valued at US$4.04 billion in 2021 and is expected to expand at a compound annual growth rate (CAGR) of 16.2% from 2022 to 2030.<\/p>\n<p>And according to the World Health Organization, the economic cost burden will range from US$1.3 trillion to US$2.8 trillion by 2030.<\/p>\n<p>Now, the latest pre-clinical data from two separate studies shows ARG-007 significantly inhibits the cellular uptake and aggregation of the tau protein in two different in vitro Alzheimer\u2019s disease models.<\/p>\n<p>The aggregation of tau protein into tangles inside brain cells, and the spread of abnormal tau within the brain through cellular uptake, is thought to be a significant cause of Alzheimer\u2019s disease, with the spread and cellular uptake of abnormal tau a key hallmark of Alzheimer\u2019s disease progression.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<h2><strong>Ideal drug candidate for neurodegenerative conditions<\/strong><\/h2>\n<p>The two studies confirm ARG-007 has the capacity to significantly reduce the uptake of abnormal tau into brain cells, with a 68% and 49% reduction seen in the two different studies, thereby potentially limiting the spread of abnormal tau between brain cells.<\/p>\n<p>They also confirm the drug inhibits intracellular tau aggregation by up to 89% in the first study and 35% in the second study.<\/p>\n<p>These studies in combination with previously reported data on the ability of ARG-007 to reduce beta-amyloid aggregation, suggests ARG-007 could have a significant impact on reducing the effects of key proteins implicated in Alzheimer\u2019s disease.<\/p>\n<p>\u201cThis ability of ARG-007 to reduce tau cellular uptake and abnormal aggregation of tau within neurons in these two preclinical studies is extremely encouraging,\u201d <a href=\"https:\/\/stockhead.com.au\/company\/argenica-therapeutics-agn\/\"><strong>Argenica Therapeutics (ASX:AGN)<\/strong><\/a> managing director Dr Liz Dallimore said.<\/p>\n<p>\u201cIt provides further confirmation that ARG-007 can act on multiple targets and in multiple ways, making it an ideal drug candidate for neurodegenerative conditions such as Alzheimer\u2019s disease.\u201d<\/p>\n<p>Currently, there are no approved drugs targeting tau protein aggregation and cellular uptake.<\/p>\n<p>\u00a0<\/p>\n<h2><strong>In vivo animal studies planned<\/strong><\/h2>\n<p>AGN is continuing to progress in vivo animal studies to further confirm the efficacy of ARG-007 in Alzheimer\u2019s disease.<\/p>\n<p>Mice will receive multiple doses of ARG-007 over an extended period of time, with results to assess the effect on beta-amyloid levels and plaques, tau protein levels, neuroinflammation, and neurodegeneration.<\/p>\n<p>The company will update the market as milestones are met.<\/p>\n<p>\u00a0<\/p>\n\n<p><span class=\"mce_SELRES_start\">\ufeff<\/span>\u00a0<\/p>\n<p><em>This article was developed in collaboration with Argenica Therapeutics, a Stockhead advertiser at the time of publishing. <\/em><\/p>\n<p><em>\u00a0<\/em><\/p>\n<p><em>This article does not constitute financial product advice. You should consider obtaining independent advice before making any financial decisions.<\/em><\/p>\n<p><span class=\"et_bloom_bottom_trigger\"><\/span><\/p>\n<p>The post <a href=\"https:\/\/stockhead.com.au\/health\/data-shows-argenicas-drug-inhibits-another-main-cause-of-alzheimers-disease\/\">Data shows Argenica\u2019s drug inhibits another main cause of Alzheimer\u2019s disease<\/a> appeared first on <a href=\"https:\/\/stockhead.com.au\/\">Stockhead<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>Argenica Therapeutics preclinical data shows ARG-007 inhibits abnormal tau proteins \u2013 a main cause of Alzheimer\u2019s disease Global Alzheimer\u2019s disease market set to grow at <a href=\"https:\/\/economicherald.net\/?p=945\" class=\"read-more-link\">[more&#8230;]<\/a><\/p>\n","protected":false},"author":0,"featured_media":946,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-945","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-finance"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - 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